Human FREM1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FREM1
Locus ID	158326
Kit Components	GA115955G1, FREM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115955G2, FREM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115955G3, FREM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177704, NM_144966, NM_001370060, NM_001370061, NM_001370065, NR_163239, NR_163240, NR_163241, NM_001370058, NM_001370063, NR_163238, NR_163242
Synonyms	BNAR; C9orf143; C9orf145; C9orf154; MOTA; TILRR; TRIGNO2
Summary	This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011]

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