Human HSCB activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HSCB
Locus ID	150274
Kit Components	GA115740G1, HSCB gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115740G2, HSCB gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115740G3, HSCB gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001318314, NM_001318315, NM_001318316, NM_172002, NR_134560, NM_001363856
Synonyms	DNAJC20; HSC20; JAC1
Summary	This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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