Human UNC45B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	UNC45B
Locus ID	146862
Kit Components	GA115588G1, UNC45B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115588G2, UNC45B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115588G3, UNC45B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033576, NM_001267052, NM_001308281, NM_173167
Synonyms	CMYA4; CTRCT43; SMUNC45; UNC-45B; UNC45
Summary	This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

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