Human TOM1L2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TOM1L2
Locus ID	146691
Kit Components	GA115570G1, TOM1L2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115570G2, TOM1L2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115570G3, TOM1L2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033551, NM_001082968, NM_001288786, NM_001288787, NM_001288788, NM_001288789, NM_144678, NM_001350331, NM_001350332, NM_001350333
Synonyms	FLJ21501; FLJ32746
Summary	This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]

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