Human TRPM6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TRPM6
Locus ID	140803
Kit Components	GA115410G1, TRPM6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115410G2, TRPM6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115410G3, TRPM6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177310, NM_001177311, NM_017662
Synonyms	CHAK2; HMGX; HOMG; HOMG1; HSH
Summary	This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]

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