Human ASZ1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ASZ1
Locus ID	136991
Kit Components	GA115277G1, ASZ1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115277G2, ASZ1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115277G3, ASZ1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001301821, NM_001301822, NM_130768, NR_023315
Synonyms	ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3
Summary	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).[UniProtKB/Swiss-Prot Function]

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