Human TRIM50 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TRIM50
Locus ID	135892
Kit Components	GA115255G1, TRIM50 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115255G2, TRIM50 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115255G3, TRIM50 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001281450, NM_001281451, NM_178125
Synonyms	TRIM50A
Summary	E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.[UniProtKB/Swiss-Prot Function]

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