Human GRPEL2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GRPEL2
Locus ID	134266
Kit Components	GA115220G1, GRPEL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115220G2, GRPEL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115220G3, GRPEL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_152407
Synonyms	Mt-GrpE#2
Summary	Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).[UniProtKB/Swiss-Prot Function]

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