Human ATPSCKMT activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATPSCKMT
Locus ID	134145
Kit Components	GA115215G1, ATPSCKMT gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115215G2, ATPSCKMT gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115215G3, ATPSCKMT gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001258388, NM_001258389, NM_199133, NR_047668, NR_047669, NR_047670
Synonyms	JS-2
Summary	Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090).[UniProtKB/Swiss-Prot Function]

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