Human LYPD6B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LYPD6B
Locus ID	130576
Kit Components	GA115120G1, LYPD6B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115120G2, LYPD6B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115120G3, LYPD6B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001317002, NM_001317003, NM_001317004, NM_001317005, NM_001317006, NM_177964
Synonyms	CT116; LYPD7
Summary	Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.[UniProtKB/Swiss-Prot Function]

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