Human DNAI3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DNAI3
Locus ID	126820
Kit Components	GA114966G1, DNAI3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114966G2, DNAI3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114966G3, DNAI3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001288563, NM_145172
Synonyms	DIC3; NYD-SP29
Summary	Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (PubMed:32128961). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (By similarity). May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (By similarity).[UniProtKB/Swiss-Prot Function]

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