Human ANKRD9 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ANKRD9
Locus ID	122416
Kit Components	GA114770G1, ANKRD9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114770G2, ANKRD9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114770G3, ANKRD9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_152326, NM_001348651, NM_001348652
Synonyms	MGC21990
Summary	Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565). Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707). Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565).[UniProtKB/Swiss-Prot Function]

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