Human LRRK2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LRRK2
Locus ID	120892
Kit Components	GA114729G1, LRRK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114729G2, LRRK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114729G3, LRRK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_198578
Synonyms	AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Summary	This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

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