Human GPCR TGR7 (MRGPRD) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MRGPRD
Locus ID	116512
Kit Components	GA114601G1, GPCR TGR7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114601G2, GPCR TGR7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114601G3, GPCR TGR7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_198923
Synonyms	MRGD; TGR7
Summary	May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).[UniProtKB/Swiss-Prot Function]

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