Human GEFT (ARHGEF25) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARHGEF25
Locus ID	115557
Kit Components	GA114531G1, GEFT gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114531G2, GEFT gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114531G3, GEFT gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001111270, NM_133483, NM_182947, NR_046223, NM_001347933
Synonyms	GEFT; p63RhoGEF
Summary	Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

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