Human LY108 (SLAMF6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SLAMF6
Locus ID	114836
Kit Components	GA114477G1, LY108 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114477G2, LY108 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114477G3, LY108 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001184714, NM_001184715, NM_001184716, NM_052931
Synonyms	CD352; KALI; KALIb; Ly108; NTB-A; NTBA; SF2000
Summary	The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

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