Human TMEM106A activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TMEM106A
Locus ID	113277
Kit Components	GA114401G1, TMEM106A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114401G2, TMEM106A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114401G3, TMEM106A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001291586, NM_001291587, NM_001291588, NM_145041
Summary	Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:30456879, PubMed:29131025).[UniProtKB/Swiss-Prot Function]

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