Human TMEM106A activation kit by CRISPRa

CAT#: GA114401

TMEM106A CRISPRa kit - CRISPR gene activation of human transmembrane protein 106A



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CNY 12255.00


货期*
4周

规格
    • 1 kit

Product images

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol TMEM106A
Locus ID 113277
Kit Components

GA114401G1, TMEM106A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114401G2, TMEM106A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114401G3, TMEM106A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Reference Data
RefSeq NM_001291586, NM_001291587, NM_001291588, NM_145041
Summary Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:30456879, PubMed:29131025).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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