Human Epithelial Stromal Interaction 1 (EPSTI1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	EPSTI1
Locus ID	94240
Kit Components	GA114342G1, Epithelial Stromal Interaction 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114342G2, Epithelial Stromal Interaction 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114342G3, Epithelial Stromal Interaction 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002264, NM_033255, NM_001330543, NM_001331228
Synonyms	BRESI1
Summary	The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE). [provided by RefSeq, Sep 2016]

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