Human SFXN1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SFXN1
Locus ID	94081
Kit Components	GA114324G1, SFXN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114324G2, SFXN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114324G3, SFXN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022754, NM_001322977, NM_001322978, NM_001322980, NM_001322981, NM_001322982, NM_001322983
Synonyms	FLJ12876
Summary	Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). Transports both D-serine and L-serine (PubMed:30442778). Also able to transport other amino-acids, such as alanine (PubMed:30442778). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).[UniProtKB/Swiss-Prot Function]

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