Human KNDC1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KNDC1
Locus ID	85442
Kit Components	GA113884G1, KNDC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113884G2, KNDC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113884G3, KNDC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_033404, NM_152643, NM_001347864, NM_001347865, NM_001347866
Synonyms	bB439H18.3; C10orf23; FLJ16067; kinase non-catalytic C-lobe domain (KIND) containing 1; RASGEF2; RASGEF2, C10orf23, FLJ16067, bB439H18.3, RP13-439H18.3; RasGEF domain family, member 2
Summary	The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]

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