Human FAPP2 (PLEKHA8) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PLEKHA8
Locus ID	84725
Kit Components	GA113675G1, FAPP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113675G2, FAPP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113675G3, FAPP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001197026, NM_001197027, NM_032639, NM_001350973, NM_001350974, NM_001350975, NM_001363473, NM_001363474
Synonyms	FAPP2
Summary	Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.[UniProtKB/Swiss-Prot Function]

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