Human KIRREL2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KIRREL2
Locus ID	84063
Kit Components	GA113347G1, KIRREL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113347G2, KIRREL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113347G3, KIRREL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001329530, NM_032123, NM_199179, NM_199180, NM_001363667
Synonyms	FILTRIN; NEPH3; NLG1
Summary	This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]

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