Human L3MBTL2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	L3MBTL2
Locus ID	83746
Kit Components	GA113260G1, L3MBTL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113260G2, L3MBTL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113260G3, L3MBTL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001003689, NM_031488
Synonyms	H-l(3)mbt-l; H-l(3)mbt-like protein; l(3)mbt-like 2; l(3)mbt-like 2 (Drosophila); L3MBT; OTTHUMP00000028919
Summary	Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.[UniProtKB/Swiss-Prot Function]

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