Human ITCH activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ITCH
Locus ID	83737
Kit Components	GA113254G1, ITCH gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113254G2, ITCH gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113254G3, ITCH gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001257137, NM_001257138, NM_031483, NM_001324197, NM_001324198
Synonyms	ADMFD; AIF4; AIP4; dJ468O1.1; NAPP1
Summary	This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

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