Human LAS1L activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LAS1L
Locus ID	81887
Kit Components	GA113147G1, LAS1L gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113147G2, LAS1L gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113147G3, LAS1L gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001170649, NM_001170650, NM_031206
Synonyms	dJ475B7.2; Las1-like; WTS
Summary	Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.[UniProtKB/Swiss-Prot Function]

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