Human TMEM49 (VMP1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	VMP1
Locus ID	81671
Kit Components	GA113107G1, TMEM49 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113107G2, TMEM49 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113107G3, TMEM49 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001329394, NM_001329395, NM_001329396, NM_001329397, NM_001329398, NM_001329399, NM_001329400, NM_001329401, NM_001329402, NM_030938
Synonyms	EPG3; TANGO5; TMEM49
Summary	This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]

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