Human ITM2C activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ITM2C
Locus ID	81618
Kit Components	GA113094G1, ITM2C gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113094G2, ITM2C gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113094G3, ITM2C gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001012514, NM_001012516, NM_001287240, NM_001287241, NM_030926
Synonyms	BRI3; BRICD2C; E25; E25C; ITM3
Summary	Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).[UniProtKB/Swiss-Prot Function]

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