Human FHOD3 activation kit by CRISPRa

CAT#: GA112866

FHOD3 CRISPRa kit - CRISPR gene activation of human formin homology 2 domain containing 3



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CNY 12255.00


货期*
4周

规格
    • 1 kit

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FHOD3 (Myc-DDK-tagged)-Human formin homology 2 domain containing 3 (FHOD3)
    • 10 ug

CNY 9848.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol FHOD3
Locus ID 80206
Kit Components

GA112866G1, FHOD3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112866G2, FHOD3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112866G3, FHOD3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Reference Data
RefSeq NM_001281739, NM_001281740, NM_025135
Synonyms FHOS2; Formactin2
Summary The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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