Human Sperm Flagellar 2 (SPEF2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SPEF2
Locus ID	79925
Kit Components	GA112734G1, Sperm Flagellar 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112734G2, Sperm Flagellar 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112734G3, Sperm Flagellar 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_024867, NM_144722
Synonyms	CT122; KPL2
Summary	Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.[UniProtKB/Swiss-Prot Function]

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