Human EHMT1/GLP (EHMT1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	EHMT1
Locus ID	79813
Kit Components	GA112645G1, EHMT1/GLP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112645G2, EHMT1/GLP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112645G3, EHMT1/GLP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001145527, NM_024757, NM_001354259, NM_001354263, NM_001354611, NM_001354612
Synonyms	bA188C12.1; Eu-HMTase1; EUHMTASE1; FP13812; GLP; GLP1; KMT1D
Summary	The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

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