Human CORO7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CORO7
Locus ID	79585
Kit Components	GA112471G1, CORO7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112471G2, CORO7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112471G3, CORO7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001201472, NM_001201473, NM_024535, NM_001351729, NR_145128
Synonyms	0610011B16Rik; CRN7; POD1
Summary	This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]

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