Human UPF3A activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	UPF3A
Locus ID	65110
Kit Components	GA112239G1, UPF3A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112239G2, UPF3A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112239G3, UPF3A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023011, NM_080687, NM_001353644, NM_001353645, NM_001353646, NM_001353647, NM_001353648, NM_001353649, NM_001353650, NM_001353651, NM_001353652, NR_148482, NR_148483, NR_148484, NR_148485, NR_148486, NR_148487, NR_148488, NR_148489, NR_148490, NR_148491, NR_148492, NR_148493, NR_148494, NR_148495, NR_148496
Synonyms	HUPF3A; RENT3A; UPF3
Summary	This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

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