Human LMBR1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LMBR1
Locus ID	64327
Kit Components	GA112040G1, LMBR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112040G2, LMBR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112040G3, LMBR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022458, NM_001350953, NM_001350954, NM_001350955, NM_001350956, NM_001350957, NM_001350958, NR_146958, NM_001363409, NM_001363410, NM_001363411, NM_001363412, NM_001363413, NR_146959
Synonyms	ACHP; C7orf2; DIF14; LSS; PPD2; THYP; TPT; ZRS
Summary	This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]

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