Human PDLIM2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDLIM2
Locus ID	64236
Kit Components	GA112026G1, PDLIM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112026G2, PDLIM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112026G3, PDLIM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_021630, NM_176871, NM_198042, NM_001368120
Synonyms	MYSTIQUE; SLIM
Summary	This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

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