Human Translation factor GUF1, mitochondrial (GUF1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GUF1
Locus ID	60558
Kit Components	GA111869G1, Translation factor GUF1, mitochondrial gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111869G2, Translation factor GUF1, mitochondrial gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111869G3, Translation factor GUF1, mitochondrial gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001345867, NM_001345868, NM_001345869, NM_021927
Synonyms	EF-4; EF4; EIEE40
Summary	This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

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