Human SIGIRR activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SIGIRR
Locus ID	59307
Kit Components	GA111821G1, SIGIRR gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111821G2, SIGIRR gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111821G3, SIGIRR gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135053, NM_001135054, NM_021805
Synonyms	IL-1R8; TIR8
Summary	Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.[UniProtKB/Swiss-Prot Function]

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