Human Spectrin beta chain, brain 3 (SPTBN4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SPTBN4
Locus ID	57731
Kit Components	GA111719G1, Spectrin beta chain, brain 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111719G2, Spectrin beta chain, brain 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111719G3, Spectrin beta chain, brain 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020971, NM_025213
Synonyms	QV; SPNB4; SPTBN3
Summary	Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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