Human ARFGEF3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARFGEF3
Locus ID	57221
Kit Components	GA111453G1, ARFGEF3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111453G2, ARFGEF3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111453G3, ARFGEF3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020340
Synonyms	A7322; BIG3; C6orf92; dJ171N11.1; PPP1R33
Summary	Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786).[UniProtKB/Swiss-Prot Function]

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