Human TWSG1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TWSG1
Locus ID	57045
Kit Components	GA111346G1, TWSG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111346G2, TWSG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111346G3, TWSG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020648
Synonyms	TSG
Summary	May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).[UniProtKB/Swiss-Prot Function]

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