Human KTEL1 (POGLUT1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	POGLUT1
Locus ID	56983
Kit Components	GA111317G1, KTEL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111317G2, KTEL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111317G3, KTEL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020231, NM_152305, NR_024265
Synonyms	C3orf9; CLP46; hCLP46; KDELCL1; MDS010; MDSRP; MGC32995
Summary	This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

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