Human ERO1LB (ERO1B) activation kit by CRISPRa
CAT#: GA111197
ERO1B CRISPRa kit - CRISPR gene activation of human endoplasmic reticulum oxidoreductase 1 beta
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | ERO1B |
Locus ID | 56605 |
Kit Components | GA111197G1, ERO1LB gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111197G2, ERO1LB gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111197G3, ERO1LB gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_019891 |
Synonyms | DKFZp779C1042; DKFZp779I0141; FLJ11003 |
Summary | Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN208445 | ERO1B - human gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN208445BN | ERO1LB - human gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN208445LP | ERO1LB - human gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN208445RB | ERO1LB - human gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN408445 | ERO1B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |