Human Girdin (CCDC88A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CCDC88A
Locus ID	55704
Kit Components	GA110898G1, Girdin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110898G2, Girdin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110898G3, Girdin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135597, NM_001254943, NM_018084, NM_001365480
Synonyms	APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212; PEHO
Summary	This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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