Human LYAR activation kit by CRISPRa
CAT#: GA110850
LYAR CRISPRa kit - CRISPR gene activation of human Ly1 antibody reactive
CNY 12255.00
CNY 9975.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | LYAR |
Locus ID | 55646 |
Kit Components | GA110850G1, LYAR gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110850G2, LYAR gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110850G3, LYAR gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_001145725, NM_017816 |
Synonyms | ZC2HC2; ZLYAR |
Summary | Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN401908 | LYAR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |