Human Protor 1 (PRR5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRR5
Locus ID	55615
Kit Components	GA110825G1, Protor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110825G2, Protor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110825G3, Protor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001017528, NM_001017529, NM_001017530, NM_001198721, NM_015366, NM_181333
Synonyms	FLJ20185k; PP610; PROTOR-1; PROTOR1
Summary	This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

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