Human HJURP activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HJURP
Locus ID	55355
Kit Components	GA110732G1, HJURP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110732G2, HJURP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110732G3, HJURP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282962, NM_001282963, NM_018410
Synonyms	FAKTS; hFLEG1; URLC9
Summary	Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.[UniProtKB/Swiss-Prot Function]

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