Human CCDC109B (MCUB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MCUB
Locus ID	55013
Kit Components	GA110452G1, CCDC109B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110452G2, CCDC109B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110452G3, CCDC109B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_017918
Synonyms	CCDC109B
Summary	Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.[UniProtKB/Swiss-Prot Function]

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