Human C12orf48 (PARPBP) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PARPBP
Locus ID	55010
Kit Components	GA110449G1, C12orf48 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110449G2, C12orf48 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110449G3, C12orf48 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001319988, NM_001319993, NM_001319994, NM_001319995, NM_001319996, NM_017915, NR_135123
Synonyms	AROM; C12orf48; PARI
Summary	Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.[UniProtKB/Swiss-Prot Function]

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