Human NDE1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NDE1
Locus ID	54820
Kit Components	GA110285G1, NDE1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110285G2, NDE1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110285G3, NDE1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001143979, NM_017668
Synonyms	HOM-TES-87; LIS4; MHAC; NDE; NUDE; NUDE1
Summary	This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

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