Human RBFOX1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RBFOX1
Locus ID	54715
Kit Components	GA110227G1, RBFOX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110227G2, RBFOX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110227G3, RBFOX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001142333, NM_001142334, NM_001308117, NM_018723, NM_145891, NM_145892, NM_145893, NM_001364800
Synonyms	2BP1; A2BP1; FOX-1; FOX1; HRNBP1
Summary	The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

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