Human RNF186 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RNF186
Locus ID	54546
Kit Components	GA110172G1, RNF186 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110172G2, RNF186 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110172G3, RNF186 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_019062
Synonyms	RP11-91K11.1
Summary	E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122). In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122).[UniProtKB/Swiss-Prot Function]

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